United States securities and exchange commission logo August 13, 2020 Mitchell Gold, M.D. Executive Chairman and Chief Executive Officer Alpine Immune Sciences, Inc. 188 East Blaine Street, Suite 200 Seattle, WA 98102 Re: Alpine Immune Sciences, Inc. Registration Statement on Form S-1 Filed August 11, 2020 File No. 333-244409 Dear Dr. Gold: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Jason L. Drory at 202-552-8342 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Bryan King, Esq.