United States securities and exchange commission logo

                           May 18, 2021

       Mitchell Gold, M.D.
       Executive Chairman and Chief Executive Officer
       Alpine Immune Sciences, Inc.
       188 East Blaine Street, Suite 200
       Seattle, WA 98102

                                                        Re: Alpine Immune
Sciences, Inc.
Statement on Form S-3
                                                            Filed May 14, 2021
                                                            File No. 333-256107

       Dear Dr. Gold:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Dillon
Hagius at 202-551-7967 with any questions.


                           Division of Corporation Finance

                           Office of Life Sciences
       cc:                                              Bryan King