United States securities and exchange commission logo

                           November 16, 2021

       Mitchell Gold
       Chief Executive Officer
       Alpine Immune Sciences, Inc.
       188 East Blaine Street, Suite 200
       Seattle, WA 98102

                                                        Re: Alpine Immune
Sciences, Inc.
Statement on Form S-3
                                                            Filed November 10,
                                                            File No. 333-260971

       Dear Dr. Gold:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jane
Park at 202-551-7439 with any questions.


                           Division of Corporation Finance

                           Office of Life Sciences
       cc:                                              Bryan King