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United States securities and exchange commission logo
November 16, 2021
Mitchell Gold
Chief Executive Officer
Alpine Immune Sciences, Inc.
188 East Blaine Street, Suite 200
Seattle, WA 98102
Re: Alpine Immune
Sciences, Inc.
Registration
Statement on Form S-3
Filed November 10,
2021
File No. 333-260971
Dear Dr. Gold:
This is to advise you that we have not reviewed and will not
review your registration
statement.
Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of
action by the staff.
Please contact Jane
Park at 202-551-7439 with any questions.
Sincerely,
Division of Corporation Finance
Office of Life Sciences
cc: Bryan King